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Article

Effects of estradiol and 4-hydroxytamoxifen on the conformation, thermal stability, and DNA recognition of estrogen receptor beta.

Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Feb 2007

Vijayanathan Veena, Greenfield Norma J, Thomas T J, Ivanova Margarita M, Tyulmenkov Valentyn V, Klinge Carolyn M, Gallo Michael A, Thomas Thresia

Abstract excerpt

Estrogen receptors (ERalpha and ERbeta) are ligand-activated transcription factors. We examined the effects of estradiol (E2), 4-hydroxytamoxifen (HT), and the estrogen response element (ERE) on the helical content and thermal unfolding of ERbeta. A circular dichroism (CD) spectrum of ERbeta showed changes at 210 and 222 nm that were due to the presence of E2, which is indicative of partial unfolding. In...

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Identifiers

PMID: 17464340
DOI: 10.1139/o06-144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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