Structure and function of the estrogen receptor.

doi:10.1111/j.1749-6632.1993.tb32276.x

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Article

Structure and function of the estrogen receptor.

Annals of the New York Academy of Sciences - 11 Jun 1993

Parker M G, Arbuckle N, Dauvois S, Danielian P, White R

Abstract excerpt

The hormone binding domain of the estrogen receptor is required not only for binding estradiol but also to form stable homodimers of the protein and mediate transcriptional activation by the receptor. Residues that are essential for estrogen binding are also involved in dimerization, suggesting t...

Topics

Animals
Estrogen Antagonists
Hormones
Humans
Mutation
Receptors, Estrogen
Transcription, Genetic

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