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Article

The transcriptional activities and cellular localization of the human estrogen receptor alpha are affected by the synonymous Ala87 mutation.

The Journal of steroid biochemistry and molecular biology - 1 Sept 2014

Fernández-Calero Tamara, Astrada Soledad, Alberti Alvaro, Horjales Sofía, Arnal Jean Francois, Rovira Carlos, Bollati-Fogolín Mariela, Flouriot Gilles, Marin Mónica

Abstract excerpt

Until recently, synonymous mutations (which do not change amino acids) have been much neglected. Some evidence suggests that this kind of mutations could affect mRNA secondary structure or stability, translation kinetics and protein structure. To explore deeper the role of synonymous mutations, we studied their consequence on the functional activity of the estrogen receptor alpha (ERα). The ERα is a...

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Identifiers

PMID: 24607813
DOI: 10.1016/j.jsbmb.2014.02.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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