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Article

p53 DNA binding can be modulated by factors that alter the conformational equilibrium.

The EMBO journal - 1 Feb 1999

McLure K G, Lee P W

Abstract excerpt

The p53 tumor suppressor protein is a dimer of dimers that binds its consensus DNA sequence (containing two half-sites) as a pair of clamps. We show here that after one wild-type dimer of a tetramer binds to a half-site on the DNA, the other (unbound) dimer can be in either the wild-type or the mutant conformation. An equilibrium state between these two conformations exists and can be modulated by two types of...

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Identifiers

PMID: 9927436
DOI: 10.1093/emboj/18.3.763
PMCID: PMC1171169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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