p53 DNA binding can be modulated by factors that alter the conformational equilibrium.

doi:10.1093/emboj/18.3.763

Back to search

Article

p53 DNA binding can be modulated by factors that alter the conformational equilibrium.

The EMBO journal - 1 Feb 1999

McLure K G, Lee P W

Abstract excerpt

The p53 tumor suppressor protein is a dimer of dimers that binds its consensus DNA sequence (containing two half-sites) as a pair of clamps. We show here that after one wild-type dimer of a tetramer binds to a half-site on the DNA, the other (unbound) dimer can be in either the wild-type or the m...

Topics

Animals
Base Sequence
Binding Sites
Consensus Sequence
DNA
Dimerization
Drug Stability
Genotype
Humans
In Vitro Techniques
Mice
Mutation
Protein Conformation
Tumor Suppressor Protein p53

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.