Article
The evolutionarily conserved arrangement of domains in SRC family kinases is important for substrate recognition.
Biochemistry - 14 Oct 2008
Yadav Shalini S, Miller W Todd
Abstract excerpt
The SH3-SH2-kinase domain arrangement in nonreceptor tyrosine kinases has been conserved throughout evolution. For Src family kinases, the relative positions of the domains are important for enzyme regulation; they permit the assembly of Src kinases into autoinhibited conformations. The SH3 and SH2 domains of Src family kinases have an additional role in determining the substrate specificity of the kinase. We...
Topics
- Amino Acid Sequence
- Biological Evolution
- Blotting, Western
- Cell Line
- Conserved Sequence
- Immunoprecipitation
- Mutation
- Substrate Specificity
- src-Family Kinases