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Article

Structural basis for specificity switching of the Src SH2 domain.

Molecular cell - 1 Jun 2000

Kimber M S, Nachman J, Cunningham A M, Gish G D, Pawson T, Pai E F

Abstract excerpt

The Src SH2 domain binds pYEEI-containing phosphopeptides in an extended conformation with a hydrophobic pocket, which includes ThrEF1, binding Ile(pY +3). Mutating ThrEF1 to tryptophan switches specificity to an Asn(pY +2) requirement, yielding a biological mimic of the Grb2 SH2 domain. Here we...

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Identifiers

PMID: 10911998
DOI: 10.1016/s1097-2765(00)80269-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10911998-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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