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Article

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation.

The Journal of biological chemistry - 30 Nov 2001

Turkson J, Ryan D, Kim J S, Zhang Y, Chen Z, Haura E, Laudano A, Sebti S, Hamilton A D, Jove R

Abstract excerpt

Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic signaling proteins that participates in normal cellular responses to cytokines and growth factors. Frequently, however, constitutive activation of certain STAT family members, particularly Stat3, has accompanied a wide variety of human malignancies. To identify small molecule inhibitors of Stat3, we investigated the...

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PMID: 11579100
DOI: 10.1074/jbc.M107527200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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