Article
Abrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms.
Molecular and cellular biology - 1 Oct 1995
Welch P J, Wang J Y
Abstract excerpt
The decision to enter the cell division cycle is governed by the interplay between growth activators and growth inhibitors. The retinoblastoma protein (RB) is an example of a growth inhibitor whose main function appears to be the binding and inactivation of key cell cycle activators. One target of RB is a proto-oncoprotein, the c-Abl tyrosine kinase. RB binds to the ATP-binding lobe in the kinase domain and...
Topics
- Adenosine Triphosphate
- Animals
- Cell Division
- Cell Line
- DNA
- Fibroblasts
- G1 Phase
- Humans
- Mice
- Mutation
- Osteosarcoma
- Phosphorylation