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Article

In vitro phosphorylation and acetylation of the murine pocket protein Rb2/p130.

PloS one - 1 Jan 2012

Saeed Muhammad, Schwarze Florian, Loidl Adele, Meraner Joachim, Lechner Markus, Loidl Peter

Abstract excerpt

The retinoblastoma protein (pRb) and the related proteins Rb2/p130 and 107 represent the "pocket protein" family of cell cycle regulators. A key function of these proteins is the cell cycle dependent modulation of E2F-regulated genes. The biological activity of these proteins is controlled by acetylation and phosphorylation in a cell cycle dependent manner. In this study we attempted to investigate the...

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Identifiers

PMID: 23029429
DOI: 10.1371/journal.pone.0046174
PMCID: PMC3454344

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vitro phosphorylation and acetylation of the murine pocket protein Rb2/p130.PMID 23029429Read ↗

The RB2/p130 gene product is a nuclear protein whose phosphorylation is cell cycle regulated.Semantic proximity Read ↗

Acetylation control of the retinoblastoma tumour-suppressor protein.Semantic proximity Read ↗

Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4.Semantic proximity Read ↗

Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1.Semantic proximity Read ↗

The amino terminus of the retinoblastoma (Rb) protein associates with a cyclin-dependent kinase-like kinase via Rb amino acids required for growth suppression.Semantic proximity Read ↗

Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteinsSemantic proximity Read ↗

Retinoblastoma protein family in cell cycle and cancer: A reviewSemantic proximity Read ↗

Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer.Semantic proximity Read ↗

Dynamic site-specific recruitment of RBP2 by pocket protein p130 modulates H3K4 methylation on E2F-responsive promoters.Semantic proximity Read ↗

pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F.Semantic proximity Read ↗

NF-kappa B-dependent induction of cyclin D1 by retinoblastoma protein (pRB) family proteins and tumor-derived pRB mutants.Semantic proximity Read ↗

Phosphorylation of the RB C-terminus regulates condensin II release from chromatin.Semantic proximity Read ↗

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