C-terminal truncation of the retinoblastoma gene product leads to functional inactivation.

doi:10.1073/pnas.87.1.6

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Article

C-terminal truncation of the retinoblastoma gene product leads to functional inactivation.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1990

Shew J Y, Lin B T, Chen P L, Tseng B Y, Yang-Feng T L, Lee W H

Abstract excerpt

Mutational inactivation of the retinoblastoma (RB) gene has been implicated in the genesis of retinoblastoma, osteosarcoma, and other human tumors. Our strategy has been to characterize naturally occurring mutants from tumor cells to pinpoint potential domains of RB protein crucial for tumor suppression. We show here that osteosarcoma cell line Saos-2 contains an abnormal endogenous RB protein of 95 kDa (p95)...

Topics

Animals
Antibodies
Base Sequence
Cell Line
Chromosome Deletion
DNA Probes
Eye Neoplasms
Genes
Humans
Immunoblotting
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neoplasm Proteins

Polymerase Chain Reaction

RNA-Directed DNA Polymerase

Restriction Mapping

Retinoblastoma

Retinoblastoma Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 1688660
DOI: 10.1073/pnas.87.1.6
PMCID: PMC53188

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1688660-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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