Article
Cytostatic activity of phenylacetate and derivatives against tumor cells. Correlation with lipophilicity and inhibition of protein prenylation.
Biochemical pharmacology - 12 Oct 1995
Hudgins W R, Shack S, Myers C E, Samid D
Abstract excerpt
The aromatic fatty acid phenylacetate, a common metabolite of phenylalanine, shows promise as a relatively non-toxic drug for cancer treatment. This slowly metabolized fatty acid alters tumor cell lipid metabolism causing, among other effects, inhibition of protein prenylation critical to maligna...
Topics
- Antimetabolites, Antineoplastic
- Cell Division
- Cell Line
- Cell Survival
- Drug Design
- Humans
- Lipid Metabolism
- Phenotype
- Phenylacetates
- Protein Prenylation
- Structure-Activity Relationship
- Tumor Cells, Cultured