Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective growth arrest and phenotypic reversion of prostate cancer cells in vitro by nontoxic pharmacological concentrations of phenylacetate.

The Journal of clinical investigation - 1 May 1993

Samid D, Shack S, Myers C E

Abstract excerpt

Differentiation therapy may provide an alternative for treatment of cancers that do not respond to cytotoxic chemotherapy or hormonal manipulations. This hypothesis led us to evaluate the effect of a nontoxic differentiation inducer, sodium phenylacetate (NaPA), on hormone-refractory prostate cancer, the second most common cause of cancer deaths in men. NaPA treatment of androgen-independent PC3 and DU145...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Division
Share to Cell Survival
Share to DNA Replication

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Nude

Share to Neoplasm Transplantation

Share to Phenotype

Share to Prostatic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 8486788
DOI: 10.1172/JCI116457
PMCID: PMC288233

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective growth arrest and phenotypic reversion of prostate cancer cells in vitro by nontoxic pharmacological concentrations of phenylacetate.PMID 8486788Read ↗

Increased susceptibility of ras-transformed cells to phenylacetate is associated with inhibition of p21ras isoprenylation and phenotypic reversion.Semantic proximity Read ↗

Multipathways for transdifferentiation of human prostate cancer cells into neuroendocrine-like phenotype.Semantic proximity Read ↗

Cytostatic activity of phenylacetate and derivatives against tumor cells. Correlation with lipophilicity and inhibition of protein prenylation.Semantic proximity Read ↗

Reversion of malignant phenotype by 5-iodo-6-amino-1,2-benzopyrone a non-covalently binding ligand of poly(ADP-ribose) polymerase.Semantic proximity Read ↗

Survival of docetaxel-resistant prostate cancer cells in vitro depends on phenotype alterations and continuity of drug exposure.Semantic proximity Read ↗

Gene expression profiling of the androgen independent prostate cancer cells demonstrates complex mechanisms mediating resistance to docetaxelSemantic proximity Read ↗

Induction of invasive phenotype by Casodex in hormone-sensitive prostate cancer cells.Semantic proximity Read ↗

Valproic Acid Addresses Neuroendocrine Differentiation of LNCaP Cells and Maintains Cell Survival.Semantic proximity Read ↗

Cellular changes in boric acid-treated DU-145 prostate cancer cells.Semantic proximity Read ↗

Inhibition of proliferation and induction of differentiation in medulloblastoma- and astrocytoma-derived cell lines with phenylacetate.Semantic proximity Read ↗

Acquisition of neuroendocrine characteristics by prostate tumor cells is reversible: implications for prostate cancer progression.Semantic proximity Read ↗

The emergence of protocadherin-PC expression during the acquisition of apoptosis-resistance by prostate cancer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.