Article
Selective growth arrest and phenotypic reversion of prostate cancer cells in vitro by nontoxic pharmacological concentrations of phenylacetate.
The Journal of clinical investigation - 1 May 1993
Samid D, Shack S, Myers C E
Abstract excerpt
Differentiation therapy may provide an alternative for treatment of cancers that do not respond to cytotoxic chemotherapy or hormonal manipulations. This hypothesis led us to evaluate the effect of a nontoxic differentiation inducer, sodium phenylacetate (NaPA), on hormone-refractory prostate can...
Topics
- Animals
- Cell Division
- Cell Survival
- DNA Replication
- Female
- Glutamine
- HLA-A3 Antigen
- Humans
- Male
- Mice
- Mice, Nude
- Neoplasm Invasiveness
- Neoplasm Transplantation
- Phenotype
- Phenylacetates
- Prostatic Neoplasms
- RNA, Neoplasm
- Suramin