Article
The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs.
The Journal of biological chemistry - 10 May 2013
Atsumi Yuko, Inase Aki, Osawa Tomoyuki, Sugihara Eiji, Sakasai Ryo, Fujimori Hiroaki, Teraoka Hirobumi, Saya Hideyuki, Kanno Masamoto, Tashiro Fumio, Nakagama Hitoshi, Masutani Mitsuko, Yoshioka Ken-ichi
Abstract excerpt
BACKGROUND: It is unclear how DNA-damaging agents target cancer cells over normal somatic cells. RESULTS: Arf/p53-dependent down-regulation of H2AX enables normal cells to survive after DNA damage. CONCLUSION: Transformed cells, which harbor mutations in either Arf or p53, are more sensitive to DNA-damaging agents. SIGNIFICANCE: Cellular transformation renders cells more susceptible to some DNA-damaging agents....
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