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Article

Dementia among elderly apolipoprotein E type 4/4 homozygotes: a prospective study.

Genetic epidemiology - 1 Jan 1995

Ganguli M, Cauley J A, DeKosky S T, Kamboh M I

Abstract excerpt

The E*4 allele of the apolipoprotein E (APOE) gene on chromosome 19 has been shown to be an age- and dose-related risk factor for Alzheimer's disease. Of 870 elderly women participating in an osteoporosis study, 13 were previously found to be homozygous for the APOE*4 allele; 1 was deceased and the rest were assessed for dementia in a "piggyback" study of dementia. One had moderate [clinical dementia rating (CDR...

Topics

Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Cohort Studies
Dementia
Female
Homozygote
Humans
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prospective Studies

Source

Identifiers

PMID: 7557352
DOI: 10.1002/gepi.1370120308

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7557352-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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