Article
Nitric oxide and ethylnitrosourea: relative mutagenicity in the p53 tumor suppressor and hypoxanthine-phosphoribosyltransferase genes.
Carcinogenesis - 1 Sept 1995
Felley-Bosco E, Mirkovitch J, Ambs S, Macé K, Pfeifer A, Keefer L K, Harris C C
Abstract excerpt
Nitric oxide (NO) is a cellular messenger which is mutagenic in bacteria and human TK6 cells and induces deamination of 5-methylcytosine (5meC) residues in vitro. The aims of this study were: (i) to investigate whether NO induces 5meC deamination in codon 248 of the p53 gene in cultured human bro...
Topics
- Base Sequence
- Bronchi
- Cell Line
- Codon
- Cyclic GMP
- Cytosine
- Diethylamines
- Ethylnitrosourea
- Genes, p53
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Male
- Methylation
- Molecular Sequence Data
- Mutagenicity Tests
- Mutagens
- Mutation
- Nitric Oxide