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Article

Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53.

19 Mar 1996

Abstract excerpt

The tumor suppressor gene product p53 plays an important role in the cellular response to DNA damage from exogenous chemical and physical mutagens. Therefore, we hypothesized that p53 performs a similar role in response to putative endogenous mutagens, such as nitric oxide (NO). We report here that exposure of human cells to NO generated from an NO donor or from overexpression of inducible nitric oxide synthase...

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Identifiers

PMID: 8637893
DOI: 10.1073/pnas.93.6.2442

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Source receipt: pubmed, retrieved 7 Sept 2026.

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