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Article

Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression

1 May 1997

Abstract excerpt

The tumor suppressor gene product p53 plays an important role in the cellular response to DNA damage. DNA damage can lead to p53‐mediated growth arrest and apoptosis. High concentrations of nitric oxide (NO) and NO metabolites such as peroxynitrite and NO 2 cause DNA damage and have been shown to be mutagenic. Furthermore, NO induces p53 accumulation and, as part of a feedback loop, p53 mediates transcriptional...

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PMID: 9194524
DOI: 10.1096/fasebj.11.6.9194524

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