Significant correlation of nitric oxide synthase activity and p53 gene mutation in stage I lung adenocarcinoma.

doi:10.1111/j.1349-7006.1998.tb03273.x

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Article

Significant correlation of nitric oxide synthase activity and p53 gene mutation in stage I lung adenocarcinoma.

Japanese journal of cancer research : Gann - 1 Jul 1998

Fujimoto H, Sasaki J, Matsumoto M, Suga M, Ando Y, Iggo R, Tada M, Saya H, Ando M

Abstract excerpt

Nitric oxide (NO) and its derivatives can directly cause DNA damage and mutation in vitro and may play a role in the multistage carcinogenic process. It has been reported that NO induces mutation in the p53 tumor suppressor gene; we therefore analyzed the relationship between NO synthase (NOS) ac...

Topics

Adenocarcinoma
Aged
DNA
Female
Genes, p53
Humans
Lung Neoplasms
Male
Middle Aged
Mutation
Nitric Oxide
Nitric Oxide Synthase

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