Article
Significant correlation of nitric oxide synthase activity and p53 gene mutation in stage I lung adenocarcinoma.
Japanese journal of cancer research : Gann - 1 Jul 1998
Fujimoto H, Sasaki J, Matsumoto M, Suga M, Ando Y, Iggo R, Tada M, Saya H, Ando M
Abstract excerpt
Nitric oxide (NO) and its derivatives can directly cause DNA damage and mutation in vitro and may play a role in the multistage carcinogenic process. It has been reported that NO induces mutation in the p53 tumor suppressor gene; we therefore analyzed the relationship between NO synthase (NOS) activity and p53 gene status in early-stage lung adenocarcinoma. Surgical samples were classified into two categories: 14...
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