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DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

15 Nov 1991

Abstract excerpt

Nitric oxide (NO), a multifaceted bioregulatory agent and an environmental pollutant, can also cause genomic alterations. In vitro, NO deaminated deoxynucleosides, deoxynucleotides, and intact DNA at physiological pH. That similar DNA damage can also occur in vivo was tested by treating Salmonella typhimurium strain TA1535 with three NO-releasing compounds, including nitroglycerin. All proved mutagenic. Observed...

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PMID: 1948068
DOI: 10.1126/science.1948068

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