Article
The C. elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomously.
Cell - 6 Oct 1995
Herman M A, Vassilieva L L, Horvitz H R, Shaw J E, Herman R K
Abstract excerpt
Mutations in the C. elegans gene lin-44 lead to reversals in the polarity of certain asymmetric cell divisions. We have discovered that lin-44 is a member of the Wnt family of genes, which encode secretory glycoproteins implicated in intercellular signaling. Both in situ hybridization experiments...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Division
- Cell Lineage
- Cell Polarity
- Chromosomes, Artificial, Yeast
- Consensus Sequence
- DNA, Complementary
- Disorders of Sex Development
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression Regulation
- Genes, Reporter
- Glycoproteins
- Helminth Proteins