Article
Cell shape and Wnt signaling redundantly control the division axis of C. elegans epithelial stem cells.
Development (Cambridge, England) - 1 Oct 2011
Wildwater Marjolein, Sander Nicholas, de Vreede Geert, van den Heuvel Sander
Abstract excerpt
Tissue-specific stem cells combine proliferative and asymmetric divisions to balance self-renewal with differentiation. Tight regulation of the orientation and plane of cell division is crucial in this process. Here, we study the reproducible pattern of anterior-posterior-oriented stem cell-like divisions in the Caenorhabditis elegans seam epithelium. In a genetic screen, we identified an alg-1 Argonaute mutant...
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