Article
A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy.
The Journal of experimental medicine - 16 Mar 2009
Louvet Cédric, Kabre Beniwende G, Davini Dan W, Martinier Nicolas, Su Maureen A, DeVoss Jason J, Rosenthal Wendy L, Anderson Mark S, Bour-Jordan Hélène, Bluestone Jeffrey A
Abstract excerpt
Autoimmune-prone nonobese diabetic mice deficient for B7-2 spontaneously develop an autoimmune peripheral neuropathy mediated by inflammatory CD4(+) T cells that is reminiscent of Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy. To determine the etiology of this disease, CD4(+) T cell hybridomas were generated from inflamed tissue-derived CD4(+) T cells. A majority of T cell...
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