Measuring pharmacogenetics in special groups: geriatrics.

Abstract excerpt

INTRODUCTION: The cytochrome P450 (CYP) enzymes oxidize about 80% of the most commonly used drugs. Older patients form a very interesting clinical group in which an increased prevalence of adverse drug reactions (ADRs) and therapeutic failures (TFs) is observed. Might CYP drug metabolism change with age, and justify the differences in drug response observed in a geriatric setting? AREAS COVERED: A complete...

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• Age Factors
• Aged
• Cytochrome P-450 Enzyme System
• DNA Methylation
• Drug-Related Side Effects and Adverse Reactions