Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic susceptibility to adverse drug reactions.

Trends in pharmacological sciences - 1 Jun 2001

Pirmohamed M, Park B K

Abstract excerpt

Adverse drug reactions (ADRs) are a major clinical problem. Genetic factors can determine individual susceptibility to both dose-dependent and dose-independent ADRs. Determinants of susceptibility include kinetic factors, such as gene polymorphisms in cytochrome P450 enzymes, and dynamic factors, such as polymorphisms in drug targets. The relative importance of these factors will depend on the nature of the ADR;...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytochrome P-450 Enzyme System
Share to Drug-Related Side Effects and Adverse Reactions
Share to Genetic Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA Antigens

Share to Pharmacogenetics

Share to Pharmacogenetics and Drug Metabolism

Share to Polymorphism, Genetic

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 11395158
DOI: 10.1016/s0165-6147(00)01717-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic susceptibility to adverse drug reactions.PMID 11395158Read ↗

Pharmacogenetics of Adverse Drug Reactions.Semantic proximity Read ↗

Genetic Risk Factors for Adverse Drug ReactionsSemantic proximity Read ↗

Genetic susceptibility to adverse effects of drugs and environmental toxicants. The role of the CYP family of enzymes.Semantic proximity Read ↗

Pharmacogenetics and adverse drug reactions.Semantic proximity Read ↗

Digging up the human genome: current progress in deciphering adverse drug reactions.Semantic proximity Read ↗

Progress in understanding the genomic basis for adverse drug reactions: a comprehensive review and focus on the role of ethnicity.Semantic proximity Read ↗

Genomics of Adverse Drug Reactions.Semantic proximity Read ↗

Epidemiology and individual susceptibility to adverse drug reactions affecting the liver.Semantic proximity Read ↗

Pharmacogenomics of adverse drug reactions: implementing personalized medicine.Semantic proximity Read ↗

Genotyping as a tool to predict adverse drug reactions.Semantic proximity Read ↗

[Improvement of medication safety by identification of genetically predisposed subjects. Personalized clinical strategies and regulatory advices].Semantic proximity Read ↗

Genetic basis of drug metabolism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.