Article
p16/CDKN2 alterations and pRb expression in oesophageal squamous carcinoma.
Molecular pathology : MP - 1 Apr 1998
Busatto G, Shiao Y H, Parenti A R, Baffa R, Ruol A, Plebani M, Rugge M
Abstract excerpt
BACKGROUND: Upregulation of the cell cycle associated genes, p16/CDKN2 and the retinoblastoma susceptibility gene (Rb), is commonly seen during the proliferation of normal cells. An inverse relation between the expression of p16/CDKN2 and Rb has been noted in many tumours, but has not yet been de...
Topics
- Aged
- Carcinoma, Squamous Cell
- DNA Mutational Analysis
- Esophageal Neoplasms
- Gene Expression
- Genes, p16
- Humans
- Immunoenzyme Techniques
- Male
- Middle Aged
- Mutation
- Neoplasm Proteins
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Retinoblastoma Protein