Article
Cell cycle-related gene abnormalities and product expression in esophageal carcinoma.
Laboratory investigation; a journal of technical methods and pathology - 1 Sept 1998
Roncalli M, Bosari S, Marchetti A, Buttitta F, Bossi P, Graziani D, Peracchia A, Bonavina L, Viale G, Coggi G
Abstract excerpt
In esophageal carcinoma, individual genetic alterations of cyclins, cyclin-dependent kinase inhibitors, and final effectors of the G1-to-S transition have been documented. Our aim was to design a comprehensive analysis of the role and clinical significance of some critical genes, namely cyclin D1...
Topics
- Carcinoma
- Cell Cycle
- Cyclin D1
- Cyclin-Dependent Kinase Inhibitor p16
- Esophageal Neoplasms
- Gene Amplification
- Gene Expression
- Genes, Retinoblastoma
- Humans
- Loss of Heterozygosity
- Methylation
- Mutation
- Retinoblastoma Protein