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Article

Loss of disabled-2 expression is an early event in esophageal squamous tumorigenesis

1 Jan 2006

Abstract excerpt

AIM: Disabled-2 (DAB2) is a candidate tumor-suppressor gene identified in ovarian cancer that negatively influences mitogenic signal transduction of growth factors and blocks ras activity. In a recent study, we observed down-regulation of DAB2 transcripts in ESCCs using cDNA microarrays. In the present study, we aimed to determine the clinical significance of loss of DAB2 protein in esophageal tumorigenesis,...

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Share to Cancer-related gene regulation
Share to Epigenetics and DNA Methylation
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Identifiers

PMID: 17009406
DOI: 10.3748/wjg.v12.i37.6041

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Source receipt: pubmed, retrieved 7 Sept 2026.

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