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Article

Absence of allelic loss in cytomegalic neurons of cortical tuber in the Eker rat model of tuberous sclerosis.

Acta neuropathologica - 1 Jan 2004

Mizuguchi Masashi, Mori Masato, Nozaki Yasuyuki, Momoi Mariko Y, Itoh Masayuki, Takashima Sachio, Hino Okio

Abstract excerpt

The Eker rat is an animal model of tuberous sclerosis caused by a mutation in the Tsc2 gene encoding a tumor suppressor protein, tuberin. According to Knudson's two-hit theory, renal carcinomas and other tumors develop in various organs. Although the incidence of brain lesions is lower in the Eker rat than in human tuberous sclerosis, a cortical tuber was recently found in the cerebrum of an Eker carrier. In this...

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Identifiers

PMID: 14566415
DOI: 10.1007/s00401-003-0778-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Absence of allelic loss in cytomegalic neurons of cortical tuber in the Eker rat model of tuberous sclerosis.PMID 14566415Read ↗

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