Article
Initiation of the phosphocholine-specific response to Proteus morganii. B cell transfectants expressing unmutated VH/VL can respond to stimulation by P. morganii antigen.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 1995
Penner S J, George J, Claflin L
Abstract excerpt
We wished to resolve a paradox of how the response to the phosphocholine (PC) determinant of Proteus morganii could be initiated from a precursor B cell whose receptor, in unmutated form as Ab, appears to be unable to bind Ag. Unmutated VH and unmutated VL constructs were co-transfected into the...
Topics
- Amino Acid Sequence
- Animals
- Antibody Formation
- Antigens, Bacterial
- B-Lymphocytes
- Calcium
- Epitopes
- Immunoglobulin D
- Immunoglobulin Heavy Chains
- Immunoglobulin Light Chains
- Immunoglobulin M
- Immunoglobulin Variable Region
- Mice
- Molecular Sequence Data
- Mutation
- Phosphorylcholine
- Proteus
- Transfection