Article
In vivo binding of mouse IgG via polyreactive surface IgM abrogates progressive lymphocytosis in prolymphocytic leukemia.
Leukemia & lymphoma - 1 Apr 1998
Weston K M, Mulligan S P, Raison R L
Abstract excerpt
Surface IgM expressed by malignant CD5+ B-cells from patients with B-chronic lymphocytic leukemia (B-CLL) has previously been shown to bind mouse Ig in what appears to be an example of polyreactive antigen-binding activity. This report demonstrates the in vitro and in vivo binding of mouse Ig to the surface of malignant B-cells from a patient with B-cell prolymphocytic leukemia (B-PLL). In vitro studies showed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.