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Article

Different MHC class I alleles compete for presentation of overlapping viral epitopes.

Immunity - 1 Jul 1995

Tussey L G, Rowland-Jones S, Zheng T S, Androlewicz M J, Cresswell P, Frelinger J A, McMichael A J

Abstract excerpt

We previously identified an HLA-B8+ donor, NW, whose lymphoblastoid cells failed to present a B8-restricted epitope from the influenza A nucleoprotein following viral infection, although added peptide could still be presented. The failure to present through HLA-B8 following viral infection appears to be specific for the NP epitope. Here, we report that donor NW makes an HLA-B2702-restricted influenza-specific CTL...

Topics

Alleles
Antigen Presentation
Antigens, Viral
Clone Cells
Epitopes
HLA-B8 Antigen
Histocompatibility Antigens Class I
Humans
T-Lymphocytes, Cytotoxic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7542549
DOI: 10.1016/1074-7613(95)90159-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7542549-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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