Article
The peptide binding specificity of HLA class I molecules is largely allele-specific and non-overlapping.
Molecular immunology - 1 Sept 1992
Carreno B M, Koenig S, Coligan J E, Biddison W E
Abstract excerpt
To understand better the specificity of peptide binding by MHC class I molecules, we have evaluated the capacity of a panel of unrelated peptides to compete for the presentation of viral peptides presented by HLA-A3 and HLA-B27. The HIV-Nef7F peptide (74-82) was presented by HLA-A3 to Nef-specifi...
Topics
- Adult
- Alleles
- Amino Acid Sequence
- Binding, Competitive
- Epitopes
- HLA-A2 Antigen
- HLA-A3 Antigen
- HLA-B Antigens
- HLA-B27 Antigen
- HLA-B37 Antigen
- Histocompatibility Antigens Class I
- Humans
- Influenza A virus
- Molecular Sequence Data
- Nucleocapsid Proteins
- Nucleoproteins
- Protein Binding
- RNA-Binding Proteins