Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The peptide binding specificity of HLA class I molecules is largely allele-specific and non-overlapping.

Molecular immunology - 1 Sept 1992

Carreno B M, Koenig S, Coligan J E, Biddison W E

Abstract excerpt

To understand better the specificity of peptide binding by MHC class I molecules, we have evaluated the capacity of a panel of unrelated peptides to compete for the presentation of viral peptides presented by HLA-A3 and HLA-B27. The HIV-Nef7F peptide (74-82) was presented by HLA-A3 to Nef-specific HLA-A3-restricted CTL lines, and the influenza nucleoprotein peptide NP(380-393) was presented by HLA-B27 to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Amino Acid Sequence
Share to Binding, Competitive

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epitopes

Share to Histocompatibility Antigens Class I

Share to Molecular Sequence Data

Share to Protein Binding

Share to RNA-Binding Proteins

Source

Identifiers

PMID: 1379681
DOI: 10.1016/0161-5890(92)90046-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The peptide binding specificity of HLA class I molecules is largely allele-specific and non-overlapping.PMID 1379681Read ↗

Several HLA alleles share overlapping peptide specificities.Semantic proximity Read ↗

HLA-A1 and HLA-A3 T cell epitopes derived from influenza virus proteins predicted from peptide binding motifs.Semantic proximity Read ↗

HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8+ T cellsSemantic proximity Read ↗

Peptide Binding to HLA-E Molecules in Humans, Nonhuman Primates, and Mice Reveals Unique Binding Peptides but Remarkably Conserved Anchor Residues.Semantic proximity Read ↗

Antibodies and lentiviruses that specifically recognize a T cell epitope derived from HIV-1 Nef protein and presented by HLA-C.Semantic proximity Read ↗

Differences in peptide presentation between B27 subtypes: the importance of the P1 side chain in maintaining high affinity peptide binding to B*2703.Semantic proximity Read ↗

Specificity and degeneracy in peptide binding to HLA-B7-like class I molecules.Semantic proximity Read ↗

Peptide binding motifs for MHC class I and II molecules.Semantic proximity Read ↗

Different HLA-B27 subtypes present the same immunodominant Epstein-Barr virus peptide.Semantic proximity Read ↗

Competition-based cellular peptide binding assays for 13 prevalent HLA class I alleles using fluorescein-labeled synthetic peptides.Semantic proximity Read ↗

Different MHC class I alleles compete for presentation of overlapping viral epitopes.Semantic proximity Read ↗

Binding and presentation of peptides derived from melanoma antigens MART-1 and glycoprotein-100 by HLA-A2 subtypes. Implications for peptide-based immunotherapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.