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Article

HLA-B27, but not HLA-B7, immunodominance to influenza is ERAP dependent.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2014

Akram Ali, Lin Aifeng, Gracey Eric, Streutker Catherine J, Inman Robert D

Abstract excerpt

Endoplasmic reticulum-associated aminopeptidase-1 (ERAP1) plays a critical role in the processing of peptides prior to binding to MHC class I molecules. In this article, we show for the first time, to our knowledge, that the HLA-B27 immunodominant influenza nucleoprotein (NP) 383-391 epitope is made as an N-terminally extended 14-mer before it is trimmed by ERAP. In the absence of ERAP, there is a significant...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HLA-B27 Antigen

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Share to Influenza A Virus, H3N2 Subtype

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Share to Spondylitis, Ankylosing

Source

Identifiers

PMID: 24835397
DOI: 10.4049/jimmunol.1400343

Genes

ERAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HLA-B27, but not HLA-B7, immunodominance to influenza is ERAP dependent.PMID 24835397Read ↗

Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27.Semantic proximity Read ↗

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