Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase.

doi:10.1128/JVI.69.8.5087-5094.1995

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Article

Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase.

Journal of virology - 1 Aug 1995

Mansky L M, Temin H M

Abstract excerpt

The level of genetic variation of human immunodeficiency virus type 1 (HIV-1), a member of the lentivirus genus of the Retroviridae family, is high relative to that of retroviruses in some other genera. The high error rates of purified HIV-1 reverse transcriptase in cell-free systems suggest an e...

Topics

Animals
Base Sequence
Cell Line
DNA Replication
DNA, Viral
Genetic Vectors
HIV Reverse Transcriptase
HIV-1
HeLa Cells
Humans
Lac Operon
Leukemia Virus, Bovine
Molecular Sequence Data
Mutation
RNA-Directed DNA Polymerase

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