Molecular basis of fidelity of DNA synthesis and nucleotide specificity of retroviral reverse transcriptases.

Abstract excerpt

Reverse transcription involves the conversion of viral genomic RNAinto proviral double-stranded DNA that integrates into the host cell genome. Cellular DNA polymerases replicate the integrated viral DNA and RNA polymerase II transcribes the proviral DNA into RNA genomes that are packaged into virions. Although mutations can be introduced at any of these replication steps, reverse transcriptase (RT) errors play a...

Topics

• Amino Acid Sequence
• DNA, Viral
• HIV Reverse Transcriptase
• HIV-1
• Models, Molecular
• Molecular Sequence Data
• Mutation
• RNA-Directed DNA Polymerase
• Recombination, Genetic
• Retroviridae
• Sequence Homology, Amino Acid
• Substrate Specificity