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Article

Fidelity of HIV-1 reverse transcriptase copying a hypervariable region of the HIV-1 env gene.

Virology - 1 Mar 1994

Ji J, Loeb L A

Abstract excerpt

The unusually high mutation frequency exhibited by the human immunodeficiency virus (HIV) is a major impediment to developing effective vaccines against the virus and to designing analogs that inhibit viral replication. To investigate the molecular basis of HIV hypermutability, we established cell-free assays to measure the fidelity of HIV-1 reverse transcriptase (RT) in copying either DNA or both RNA and DNA...

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Source

Identifiers

PMID: 7510083
DOI: 10.1006/viro.1994.1130

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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