Fidelity of HIV-1 reverse transcriptase copying a hypervariable region of the HIV-1 env gene.

doi:10.1006/viro.1994.1130

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Article

Fidelity of HIV-1 reverse transcriptase copying a hypervariable region of the HIV-1 env gene.

Virology - 1 Mar 1994

Ji J, Loeb L A

Abstract excerpt

The unusually high mutation frequency exhibited by the human immunodeficiency virus (HIV) is a major impediment to developing effective vaccines against the virus and to designing analogs that inhibit viral replication. To investigate the molecular basis of HIV hypermutability, we established cel...

Topics

Base Sequence
DNA, Viral
Genes, env
HIV Reverse Transcriptase
HIV-1
Molecular Sequence Data
Mutation
RNA, Viral
RNA-Directed DNA Polymerase
Templates, Genetic

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