Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional inaccuracy threshold attenuates differences in RNA-dependent DNA synthesis fidelity between retroviral reverse transcriptases.

Scientific reports - 12 Jan 2018

Sebastián-Martín Alba, Barrioluengo Verónica, Menéndez-Arias Luis

Abstract excerpt

In M13mp2 lacZα forward mutation assays measuring intrinsic fidelity of DNA-dependent DNA synthesis, wild-type human immunodeficiency virus type 1 (HIV-1) RTs of group M/subtype B previously showed >10-fold higher error rates than murine leukaemia virus (MLV) and avian myeloblastosis virus (AMV) RTs. An adapted version of the assay was used to obtain error rates of RNA-dependent DNA synthesis for several RTs,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Viral
Share to HIV-1
Share to Leukemia Virus, Murine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Retroviridae

Share to RNA-Directed DNA Polymerase

Share to RNA, Viral

Share to Transcription, Genetic

Share to Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 29330371
DOI: 10.1038/s41598-017-18974-8
PMCID: PMC5766491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional inaccuracy threshold attenuates differences in RNA-dependent DNA synthesis fidelity between retroviral reverse transcriptases.PMID 29330371Read ↗

Physiological magnesium concentrations increase fidelity of diverse reverse transcriptases from HIV-1, HIV-2, and foamy virus, but not MuLV or AMV.Semantic proximity Read ↗

Molecular basis of fidelity of DNA synthesis and nucleotide specificity of retroviral reverse transcriptases.Semantic proximity Read ↗

Altered error specificity of RNase H-deficient HIV-1 reverse transcriptases during DNA-dependent DNA synthesis.Semantic proximity Read ↗

Fidelity of HIV-1 reverse transcriptase copying RNA in vitro.Semantic proximity Read ↗

Intrinsic DNA synthesis fidelity of xenotropic murine leukemia virus-related virus reverse transcriptase.Semantic proximity Read ↗

Temperature effects on the fidelity of a thermostable HIV-1 reverse transcriptase.Semantic proximity Read ↗

Unequal human immunodeficiency virus type 1 reverse transcriptase error rates with RNA and DNA templates.Semantic proximity Read ↗

The impact of multidideoxynucleoside resistance-conferring mutations in human immunodeficiency virus type 1 reverse transcriptase on polymerase fidelity and error specificity.Semantic proximity Read ↗

Higher fidelity of RNA-dependent DNA mispair extension by M184V drug-resistant than wild-type reverse transcriptase of human immunodeficiency virus type 1.Semantic proximity Read ↗

Increased misincorporation fidelity observed for nucleoside analog resistance mutations M184V and E89G in human immunodeficiency virus type 1 reverse transcriptase does not correlate with the overall error rate measured in vitro.Semantic proximity Read ↗

Differential Influence of Nucleoside Analog-resistance Mutations K65R and L74V on the Overall Mutation Rate and Error Specificity of Human Immunodeficiency Virus Type 1 Reverse TranscriptaseSemantic proximity Read ↗

Fidelity of HIV-1 reverse transcriptase copying a hypervariable region of the HIV-1 env gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.