Article
Unequal human immunodeficiency virus type 1 reverse transcriptase error rates with RNA and DNA templates.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1992
Boyer J C, Bebenek K, Kunkel T A
Abstract excerpt
Sequence variation in the type 1 human immunodeficiency virus (HIV-1) results, in part, from inaccurate replication by reverse transcriptase. Although this enzyme is error-prone during synthesis in vitro with DNA templates, the fidelity of RNA-dependent DNA synthesis relevant to minus-strand repl...
Topics
- Avian Myeloblastosis Virus
- Base Sequence
- DNA Replication
- DNA, Viral
- Frameshift Mutation
- Genetic Variation
- HIV Reverse Transcriptase
- HIV-1
- Molecular Sequence Data
- Mutation
- RNA, Viral
- RNA-Directed DNA Polymerase
- Recombinant Proteins
- Templates, Genetic
- Transcription, Genetic