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Article

Unequal human immunodeficiency virus type 1 reverse transcriptase error rates with RNA and DNA templates.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1992

Boyer J C, Bebenek K, Kunkel T A

Abstract excerpt

Sequence variation in the type 1 human immunodeficiency virus (HIV-1) results, in part, from inaccurate replication by reverse transcriptase. Although this enzyme is error-prone during synthesis in vitro with DNA templates, the fidelity of RNA-dependent DNA synthesis relevant to minus-strand replication in the virus life cycle has not been examined extensively. In the present study, we have developed a system to...

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Identifiers

PMID: 1379727
DOI: 10.1073/pnas.89.15.6919
PMCID: PMC49616

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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