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Article

Unpredicted phenotypes of two mutants of the TcR DMF5.

Journal of immunological methods - 1 Oct 2015

Tadesse Fitsum G, Mensali Nadia, Fallang Lars-Egil, Walseng Even, Yang Weiwen, Olweus Johanna, Wälchli Sébastien

Abstract excerpt

When a T-cell Receptor (TcR) interacts with its cognate peptide-MHC (pMHC), it triggers activation of a signaling cascade that results in the elicitation of a T cell effector function. Different models have been proposed to understand which parameters are needed to obtain an optimal activation of the signaling. It was speculated that improving the binding of a TcR could bring a stronger pMHC recognition, hence a...

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Identifiers

PMID: 26079729
DOI: 10.1016/j.jim.2015.06.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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