Article
Unpredicted phenotypes of two mutants of the TcR DMF5.
Journal of immunological methods - 1 Oct 2015
Tadesse Fitsum G, Mensali Nadia, Fallang Lars-Egil, Walseng Even, Yang Weiwen, Olweus Johanna, Wälchli Sébastien
Abstract excerpt
When a T-cell Receptor (TcR) interacts with its cognate peptide-MHC (pMHC), it triggers activation of a signaling cascade that results in the elicitation of a T cell effector function. Different models have been proposed to understand which parameters are needed to obtain an optimal activation of the signaling. It was speculated that improving the binding of a TcR could bring a stronger pMHC recognition, hence a...
Topics
- Antigens, Neoplasm
- Cell Line
- Half-Life
- Humans
- Kinetics
- Melanoma
- Mutation
- Peptides
- Phenotype
- Protein Binding
- Receptors, Antigen, T-Cell
- T-Lymphocytes