Article
The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation.
Immunity - 1 Jun 1994
Kawabe T, Naka T, Yoshida K, Tanaka T, Fujiwara H, Suematsu S, Yoshida N, Kishimoto T, Kikutani H
Abstract excerpt
An engagement of CD40 with CD40 ligand (CD40L) expressed on activated T cells is known to provide an essential costimulatory signal to B cells in vitro. To investigate the role of CD40 in in vivo immune responses, CD40-deficient mice were generated by gene targeting. The significant reduction of...
Topics
- Animals
- Antibody Formation
- Antigens, CD
- Antigens, Differentiation, B-Lymphocyte
- Antigens, T-Independent
- B-Lymphocytes
- Base Sequence
- CD40 Antigens
- DNA Primers
- Female
- Gene Targeting
- Granulocytes
- Humans
- Immunoglobulin Class Switching
- Immunoglobulin M
- Immunohistochemistry
- Job Syndrome
- Leukocyte Count