Mice doubly deficient in the genes for P0 and myelin basic protein show that both proteins contribute to the formation of the major dense line in peripheral nerve myelin.

Abstract excerpt

In search for the molecular mechanisms underlying the formation of the major dense line in peripheral nerve myelin we investigated mice deficient in the myelin proteins P0 and MBP. In mice lacking both molecules axons were enwrapped by myelin-like processes devoid of the major dense line, while m...

Topics

• Animals
• Cell Adhesion Molecules, Neuronal
• Genotype
• Mice
• Mice, Knockout
• Mice, Neurologic Mutants
• Microscopy, Electron
• Myelin Basic Protein
• Myelin P0 Protein
• Myelin Proteins
• Myelin Sheath
• Peripheral Nerves
• Phenotype
• Reference Values
• Sciatic Nerve