Article
Accelerated demyelination of peripheral nerves in mice deficient in connexin 32 and protein zero.
Journal of neuroscience research - 1 Sept 1998
Neuberg D H, Carenini S, Schachner M, Martini R, Suter U
Abstract excerpt
Mutant mice that lack either protein zero (P0) or connexin 32 (Cx32) were generated previously to investigate the function of these myelin proteins in peripheral nerves and to assess the value of these mice as animal models for hereditary human peripheral neuropathies. Mice that are completely de...
Topics
- Alleles
- Animals
- Axons
- Connexins
- Demyelinating Diseases
- Heterozygote
- Homozygote
- Mice
- Mutation
- Myelin P0 Protein
- Myelin Sheath
- Paralysis
- Peripheral Nerves
- Phenotype
- Reverse Transcriptase Polymerase Chain Reaction
- Schwann Cells
- Walking
- Gap Junction beta-1 Protein