Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Accelerated demyelination of peripheral nerves in mice deficient in connexin 32 and protein zero.

Journal of neuroscience research - 1 Sept 1998

Neuberg D H, Carenini S, Schachner M, Martini R, Suter U

Abstract excerpt

Mutant mice that lack either protein zero (P0) or connexin 32 (Cx32) were generated previously to investigate the function of these myelin proteins in peripheral nerves and to assess the value of these mice as animal models for hereditary human peripheral neuropathies. Mice that are completely devoid of P0 expression (P0(+/0)) show a complex phenotype that is characterized by hypomyelination, compromised myelin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Axons
Share to Heterozygote

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Homozygote

Share to Mutation

Share to Phenotype

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 9726425
DOI: 10.1002/(SICI)1097-4547(19980901)53:5<542::AID-JNR4>3.0.CO;2-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Accelerated demyelination of peripheral nerves in mice deficient in connexin 32 and protein zero.PMID 9726425Read ↗

Connexin32-null mice develop demyelinating peripheral neuropathySemantic proximity Read ↗

Structural abnormalities and deficient maintenance of peripheral nerve myelin in mice lacking the gap junction protein connexin 32.Semantic proximity Read ↗

Altered molecular architecture of peripheral nerves in mice lacking the peripheral myelin protein 22 or connexin32.Semantic proximity Read ↗

Molecular anatomy and genetics of myelin proteins in the peripheral nervous system.Semantic proximity Read ↗

Preserved myelin integrity and reduced axonopathy in connexin32-deficient mice lacking the recombination activating gene-1.Semantic proximity Read ↗

Transgenic expression of human connexin32 in myelinating Schwann cells prevents demyelination in connexin32-null mice.Semantic proximity Read ↗

Protein zero (P0)-deficient mice show myelin degeneration in peripheral nerves characteristic of inherited human neuropathies.Semantic proximity Read ↗

Formation and maintenance of the myelin sheath in the peripheral nerve: roles of cell adhesion molecules and the gap junction protein connexin 32.Semantic proximity Read ↗

The effects of a dominant connexin32 mutant in myelinating Schwann cells.Semantic proximity Read ↗

Nerve conduction abnormalities and neuromyotonia in genetically engineered mouse models of human hereditary neuropathies.Semantic proximity Read ↗

The absence of myelin P0 protein produces a novel molecular phenotype in Schwann cells.Semantic proximity Read ↗

Altered gene expression in Schwann cells of connexin32 knockout animals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.