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Article

Upregulation of large myelin protein zero leads to Charcot-Marie-Tooth disease-like neuropathy in mice.

Communications biology - 13 Mar 2020

Otani Yoshinori, Ohno Nobuhiko, Cui Jingjing, Yamaguchi Yoshihide, Baba Hiroko

Abstract excerpt

Charcot-Marie-Tooth (CMT) disease is a hereditary neuropathy mainly caused by gene mutation of peripheral myelin proteins including myelin protein zero (P0, MPZ). Large myelin protein zero (L-MPZ) is an isoform of P0 that contains an extended polypeptide synthesized by translational readthrough at the C-terminus in tetrapods, including humans. The physiological role of L-MPZ and consequences of an altered...

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Identifiers

PMID: 32170207
DOI: 10.1038/s42003-020-0854-z
PMCID: PMC7070019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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