Article
Transcriptional upregulation of myelin components in spontaneous myelin basic protein-deficient mice.
Brain research - 5 May 2015
Staats Kim A, Pombal Diana, Schönefeldt Susann, Van Helleputte Lawrence, Maurin Hervé, Dresselaers Tom, Govaerts Kristof, Himmelreich Uwe, Van Leuven Fred, Van Den Bosch Ludo, Dooley James, Humblet-Baron Stephanie, Liston Adrian
Abstract excerpt
Myelin is essential for efficient signal transduction in the nervous system comprising of multiple proteins. The intricacies of the regulation of the formation of myelin, and its components, are not fully understood. Here, we describe the characterization of a novel myelin basic protein (Mbp) mutant mouse, mbp(jive), which spontaneously occurred in our mouse colony. These mice displayed the onset of a shaking...
Topics
- Animals
- Brain
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Motor Activity
- Mutation
- Myelin Basic Protein
- Myelin Sheath
- Phenotype
- Signal Transduction
- Transcriptional Activation
- Up-Regulation