Article
Protein zero (P0)-deficient mice show myelin degeneration in peripheral nerves characteristic of inherited human neuropathies.
Nature genetics - 1 Nov 1995
Martini R, Zielasek J, Toyka K V, Giese K P, Schachner M
Abstract excerpt
Mutations in the human gene for the myelin recognition molecule protein zero (P0) give rise to severe and progressive forms of dominantly inherited peripheral neuropathies. We have previously reported that mice homozygous for a null mutation in P0 have severely hypomyelinated nerves ten weeks aft...
Topics
- Animals
- Charcot-Marie-Tooth Disease
- Disease Models, Animal
- Hereditary Sensory and Motor Neuropathy
- Heterozygote
- Homozygote
- Humans
- Mice
- Mutation
- Myelin P0 Protein
- Myelin Sheath
- Nerve Fibers, Myelinated
- Neural Conduction
- Peripheral Nervous System Diseases
- Tenascin