Article
A major role for VCAM-1, but not ICAM-1, in early atherosclerosis.
The Journal of clinical investigation - 1 May 2001
Cybulsky M I, Iiyama K, Li H, Zhu S, Chen M, Iiyama M, Davis V, Gutierrez-Ramos J C, Connelly P W, Milstone D S
Abstract excerpt
VCAM-1 and ICAM-1 are endothelial adhesion molecules of the Ig gene superfamily that may participate in atherogenesis by promoting monocyte accumulation in the arterial intima. Both are expressed in regions predisposed to atherosclerosis and at the periphery of established lesions, while ICAM-1 is also expressed more broadly. To evaluate functions of VCAM-1 in chronic disease, we disrupted its fourth Ig domain,...
Topics
- Animals
- Aorta
- Arteriosclerosis
- Diet, Atherogenic
- Embryo Loss
- Intercellular Adhesion Molecule-1
- Leukocyte Count
- Mice
- Mice, Mutant Strains
- Mutation
- Time Factors