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Article

Efficient extension of a misaligned tRNA-primer during replication of the HIV-1 retrovirus.

Nucleic acids research - 25 Apr 1995

Das A T, Berkhout B

Abstract excerpt

The human immunodeficiency virus (HIV) and other retroviruses show extensive genomic variation, which is primarily due to error-prone replication by the viral reverse transcriptase (RT) enzymes. RT errors include misincorporation with subsequent extension of the mismatched terminal base, and extension of realigned primer-template duplexes. Whereas both RT-mediated mechanisms have been extensively studied in...

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Identifiers

PMID: 7538660
DOI: 10.1093/nar/23.8.1319
PMCID: PMC306856

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