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Article

JC virus small T antigen binds phosphatase PP2A and Rb family proteins and is required for efficient viral DNA replication activity.

PloS one - 12 May 2010

Bollag Brigitte, Hofstetter Catherine A, Reviriego-Mendoza Marta M, Frisque Richard J

Abstract excerpt

BACKGROUND: The human polyomavirus, JC virus (JCV) produces five tumor proteins encoded by transcripts alternatively spliced from one precursor messenger RNA. Significant attention has been given to replication and transforming activities of JCV's large tumor antigen (TAg) and three T' proteins, but little is known about small tumor antigen (tAg) functions. Amino-terminal sequences of tAg overlap with those of...

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Source

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Identifiers

PMID: 20485545
DOI: 10.1371/journal.pone.0010606
PMCID: PMC2868895

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Source receipt: pubmed, retrieved 7 Sept 2026.

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