Article
Differentiation and survival influences of growth factors in human neuroblastoma.
European journal of cancer (Oxford, England : 1990) - 1 Jan 1995
Påhlman S, Hoehner J C, Nånberg E, Hedborg F, Fagerström S, Gestblom C, Johansson I, Larsson U, Lavenius E, Ortoft E
Abstract excerpt
Human neuroblastoma cell lines are established from high-stage, highly malignant tumours. Despite this and the fact that these tumours are arrested at an early, immature stage, many cell lines have the capacity to undergo neuronal differentiation under proper growth conditions. One such cell line is the noradrenergic SH-SY5Y cell line. These cells can be induced to mature by a variety of modalities, resulting in...
Topics
- Cell Differentiation
- Growth Substances
- Humans
- Insulin-Like Growth Factor I
- Insulin-Like Growth Factor II
- Neoplastic Stem Cells
- Neuroblastoma
- Phenotype
- Protein Kinase C
- Tetradecanoylphorbol Acetate