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Article

Reactive oxygen species, Ki-Ras, and mitochondrial superoxide dismutase cooperate in nerve growth factor-induced differentiation of PC12 cells.

The Journal of biological chemistry - 30 Jul 2010

Cassano Silvana, Agnese Savina, D'Amato Valentina, Papale Massimo, Garbi Corrado, Castagnola Patrizio, Ruocco Maria Rosaria, Castellano Immacolata, De Vendittis Emmanuele, Santillo Mariarosaria, Amente Stefano, Porcellini Antonio, Avvedimento Enrico Vittorio

Abstract excerpt

Nerve growth factor (NGF) induces terminal differentiation in PC12, a pheochromocytoma-derived cell line. NGF binds a specific receptor on the membrane and triggers the ERK1/2 cascade, which stimulates the transcription of neural genes. We report that NGF significantly affects mitochondrial metabolism by reducing mitochondrial-produced reactive oxygen species and stabilizing the electrochemical gradient. This is...

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Identifiers

PMID: 20495008
DOI: 10.1074/jbc.M109.098525
PMCID: PMC2911279

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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